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Jan H J Hoeijmakers Selected Research

DNA Repair-Deficiency Disorders (Chromosome Instability Syndromes)

1/2021Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair-deficient mice.
1/2017Frontline Science: Tryptophan restriction arrests B cell development and enhances microbial diversity in WT and prematurely aging Ercc1-/Δ7 mice.
4/2009Congenital DNA repair deficiency results in protection against renal ischemia reperfusion injury in mice.
7/2004A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A.

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Jan H J Hoeijmakers Research Topics

Disease

15Neoplasms (Cancer)
03/2021 - 07/2004
6Trichothiodystrophy Syndromes
01/2021 - 05/2002
6Xeroderma Pigmentosum (Kaposi's Disease)
02/2016 - 01/2002
5Reperfusion Injury
11/2020 - 02/2010
5Cockayne Syndrome (Syndrome, Cockayne)
02/2007 - 01/2002
4DNA Repair-Deficiency Disorders (Chromosome Instability Syndromes)
01/2021 - 07/2004
4Hypersensitivity (Allergy)
01/2019 - 12/2005
4Genomic Instability
02/2016 - 08/2008
3Breast Neoplasms (Breast Cancer)
02/2016 - 05/2014
3Inflammation (Inflammations)
01/2014 - 02/2010
2Skin Neoplasms (Skin Cancer)
02/2016 - 01/2005
2Ischemia
06/2011 - 05/2011
2Insulin Resistance
02/2010 - 04/2009
2Hypoglycemia (Reactive Hypoglycemia)
01/2007 - 12/2006
1Neurodevelopmental Disorders
01/2021
1Polyploidy
01/2019
1Osteoporosis
01/2019
1Fever (Fevers)
12/2017
1Mitochondrial Diseases (Mitochondrial Disease)
01/2017
1Chromosome Breakage
02/2016
1Urinary Bladder Neoplasms (Bladder Cancer)
01/2015
1Complementation Group C Xeroderma Pigmentosum
01/2015
1Wounds and Injuries (Trauma)
12/2014
1Inborn Genetic Diseases (Disease, Hereditary)
12/2014
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
05/2014
1UV-Sensitive Syndrome
05/2012
1Cognitive Dysfunction
03/2012
1Memory Disorders (Memory Loss)
03/2012
1Deaf-Blind Disorders
02/2012
1Acute-Phase Reaction
12/2011
1Malnutrition (Nutritional Deficiencies)
05/2011
1Gliosis
10/2010
1Aspiration Pneumonia
10/2009
1Starvation
08/2008
1Dwarfism
12/2006
1Premature Aging
12/2006
1Cerebellar Ataxia (Dysmetria)
12/2006
1Progeria (Hutchinson Gilford Syndrome)
08/2006
1Ataxia Telangiectasia (Louis Bar Syndrome)
05/2006
1Fanconi Anemia (Fanconi's Anemia)
12/2005
1Carcinogenesis
01/2005
1Weight Loss (Weight Reduction)
09/2004
1Contact Dermatitis (Eczema, Contact)
10/2003
1Male Infertility (Male Sterility)
02/2002

Drug/Important Bio-Agent (IBA)

13Proteins (Proteins, Gene)FDA Link
01/2021 - 01/2002
6DNA (Deoxyribonucleic Acid)IBA
02/2016 - 12/2005
4NucleotidesIBA
04/2009 - 08/2006
3Transcription Factor TFIIHIBA
01/2019 - 07/2004
3Pharmaceutical PreparationsIBA
10/2018 - 01/2016
2MicroRNAs (MicroRNA)IBA
05/2014 - 12/2011
2Glucose (Dextrose)FDA LinkGeneric
10/2011 - 04/2009
2AntioxidantsIBA
02/2010 - 01/2007
2A-Form DNA (A-DNA)IBA
02/2007 - 05/2002
2Insulin-Like PeptidesIBA
01/2007 - 12/2006
2Growth Hormone (Somatotropin)IBA
01/2007 - 12/2006
2Deoxyribodipyrimidine Photo-LyaseIBA
11/2006 - 01/2005
1Sirolimus (Rapamycin)FDA Link
01/2021
1SulfurIBA
01/2021
1Activins (Activin)IBA
01/2019
1LigandsIBA
01/2019
1PlatinumIBA
10/2018
1transcription factor TFIIE (TFIIE)IBA
12/2017
1Tryptophan (L-Tryptophan)FDA Link
01/2017
1CytokinesIBA
01/2017
1EndonucleasesIBA
02/2016
1Cyclophosphamide (Cytoxan)FDA LinkGeneric
02/2016
1Doxorubicin (Adriamycin)FDA LinkGeneric
02/2016
1NexusIBA
01/2016
1Biomarkers (Surrogate Marker)IBA
01/2015
1platelet-derived growth factor AIBA
12/2014
1Platelet-Derived Growth FactorIBA
12/2014
1Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
09/2014
1Poly(ADP-ribose) Polymerase InhibitorsIBA
09/2014
1ProteomeIBA
07/2014
1Insulin (Novolin)FDA Link
02/2010
1Proliferating Cell Nuclear Antigen (PCNA)IBA
08/2008
1Biological ProductsIBA
08/2008
1Oxygen (Dioxygen)IBA
03/2008
1Mitomycin (Mitomycin-C)FDA LinkGeneric
03/2007
1Liver GlycogenIBA
01/2007
1Blood Glucose (Blood Sugar)IBA
12/2006
1Peptides (Polypeptides)IBA
06/2006
1Phosphotransferases (Kinase)IBA
05/2006
1DNA HelicasesIBA
12/2005
1Fanconi Anemia Complementation Group ProteinsIBA
12/2005
1EnzymesIBA
01/2005
1Diethylhexyl Phthalate (DEHP)IBA
09/2004
1RNA Polymerase II (RNA Polymerase B)IBA
07/2004
1Picryl Chloride (Trinitrochlorobenzene)IBA
10/2003
1UbiquitinIBA
02/2002

Therapy/Procedure

6Diet Therapy (Therapy, Diet)
01/2021 - 02/2010
4Therapeutics
03/2021 - 05/2014
3Drug Therapy (Chemotherapy)
02/2016 - 07/2004
1Kidney Transplantation
01/2014
1Hepatectomy
06/2011
1Denervation
10/2010
1General Anesthesia
10/2009
1Transjugular Intrahepatic Portasystemic Shunt
12/2005